ORAL FLUID BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERISTICS IN CHILDREN WITH ABNORMALITIES AFTER URANOPLASTY

ORAL FLUID BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERISTICS IN CHILDREN WITH ABNORMALITIES AFTER URANOPLASTY

Authors

  • Anvarova Muhtasar Anvarovna

DOI:

https://doi.org/10.5281/zenodo.18472765

Keywords:

salivation, gingivitis, intraoral fluid biochemistry, surgical palate deformity, congenital cleft palate

Abstract

To compare the physico-chemical and biochemical properties of oral fluid in children with residual defects after
uranoplasty associated with congenital cleft palate with those of a control group of healthy children. The study comprised
109 children aged 6–12 years with congenital cleft palate and residual defects after uranoplasty, as well as 50 practically
healthy children of the same age. The oral fluid of children with congenital cleft palate and residual defects that developed
after uranoplasty exhibited substantial deviations in its physicochemical and biochemical characteristics. Furthermore,
these data serve as a foundation for the further development of methods designed to improve the composition of oral fluid

Author Biography

Anvarova Muhtasar Anvarovna

Samarkand State Medical University
Independent researcher


References

Mitropanova M. N. Features of the functioning of the immune system in children with congenital cleft lip and palate at

the stages of surgical treatment. Dentistry of Childhood and Prevention. 2017;16(61):79–83. (In Russ.). Available at:

https://www.elibrary.ru/item.asp?id=29206060

Nesterova I.V., Mitropanova M.N., Chudilova G.A., Lomtatidze L.V., Gaivoronskaya T.V. Effect of imbalance of regulatory

cytokines and osteocalcin on osteogenesis in children with congenital cleft lip and palate in postnatal ontogenesis.

Dentistry. 2020;99(1):77–81. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=42479509

Rogova L.N., Fomenko I.V., Timoshenko A.N. Immunological and microbiological characteristics of the oral mucosa in

children with congenital cleft lip and palate (literature review). Volgograd Scientific Medical Journal. 2016;3(51):19–22.

(In Russ.). Available at: https://www.elibrary.ru/item.asp?id=27249177

Khripach L.V., Knyazeva T.D., Zheleznyak E.V., Makovetskaya A.K., Koganova Z.I., Budarina O.V., Lebedeva N.V.,

Ingel F.I., Demina N.N.. Adaptive changes in biochemical and immunological parameters of mixed saliva under the

influence of atmospheric air pollution on preschool children. International Journal of Applied and Basic Research.

;6:68–73. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=38489006

Kovalevsky A.M., Kovalevsky V.A. Etiology and pathogenesis of inflammatory periodontal diseases (literature review).

Part 1. Institute of Dentistry. 2017;4:88–90. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=32302028

Dovbnya Zh.A., Golovskaya G.G., Galkina O.P., Ter-pogosyan D.A., Ablaev K.D., Ablaev K.D. Changes in the factors

of nonspecific protection of the oral cavity in children with gingivitis against the background of the use of essential

oils and bentonite clay. Bulletin of Modern Clinical Medicine. 2021;14(6):33–37. (In Russ.). Available at: https://www.

elibrary.ru/item.asp?id=47463336

Osokina A.S., Maslak E.E., Yakovlev A.T. The level of immunoglobulin A in saliva depending on the presence and

severity of early childhood caries. Dentistry of Childhood and Prevention. 2020;20(4(76)):304–309. (In Russ.). Available

at: https://www.elibrary.ru/item.asp?id=44583346

Danilova M.A., Aleksandrova L.I. Quality of life in children with congenital cleft lip and palate. Dentistry of Childhood

and Prevention. 2018;17(3):54–57. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=36347137

Shevchenko O.L., Antonova A.A. The composition of mixed saliva and indicators of caries in deciduous teeth and

its complications in children. Endodontics Today. 2015; 4:8–11. (In Russ.). Available at: https://www.elibrary.ru/item.

asp?id=25411139

Kuriakose S., Sundaresan C., Mathai V., et al. A comparative study of salivary buffering capacity, flow rate, resting pH,

and salivary immunoglobulin A in children with rampant caries and caries-resistant children. J Indian Soc Pedod Prev

Dent. 2013;31(2):69–73. doi: 10.4103/0970-4388.115697

Skripkina G.I. Clinical and laboratory parameters of the subclinical course of the carious process in childhood. Dentistry

of Childhood and Prevention. 2017;16(4):24–27. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=32389346

Musakhodzhaeva D.A., Inoyatov A.Sh., Yakubov Sh.N. Some indicators of the immune system of children with

congenital cleft lip and palate. Problems of Biology and Medicine. 2011;4(67):33. (In Russ.).

Agayeva N.A. The role of secretory IgA in the pathology of the maxillofacial region. Basic Research. 2010; 4:11–16. (In

Russ.). Available at: https://www.elibrary.ru/item.asp?id=15107695

Kaur A., Kwatra K.S., Kamboj P. Evaluation of nonmicrobial salivary caries activity parameters and salivary biochemical

indicators in predicting dental caries. J Indian Soc Pedod Prev Dent. 2012;30(3):212–217. doi: 10.4103/0970-

105013

Kubala E., Strzelecka P., Grzegocka M., et al. A review of selected studies that determine the physical and chemical

properties of saliva in the field of dental treatment. BioMed Research International. 2018; ID 6572381:13. doi:

1155/2018/6572381

Hemadi A.S., Huang R., Zhou Y, Zou J. Salivary proteins and microbiota as biomarkers for early childhood caries risk

assessment. Int J Oral Sci. 2017;9(11):e1. doi: 10.1038/ijos.2017.35

Al Amoudi N., Al Shukairy H., Hanno A. A comparative study of the secretory IgA immunoglobulins (sIgA) in mothers

and children with SECC versus a caries-free group of children and their mothers. J Clin Pediatr Dent. 2007;32(1):53–

doi: 10.17796/jcpd.32.1.l338366jw54634q5

Lo Giudice G., Nicita F., Militi A., et al. Correlation of s-IgA and IL-6 salivary with caries disease and oral hygiene

parameters in children. Dent J (Basel). 2019;8(1):3. doi: 10.3390/dj8010003

Parisotto T.M., King W.F., Duque C., et al. Immunological and microbiologic changes during caries development in

young children. Caries Res. 2011;45(4):377–385. doi: 10.1159/000330230

Dovbnya Zh.A., Kolesnik K.A., Golovskaya G.G. Protective reactions of the oral cavity in children with chronic catarrhal

gingivitis and its treatment. Dentistry of Childhood and Prevention. 2017;16(2):24–26. (In Russ.). Available at: https://

www.elibrary.ru/item.asp?id=29206046

Pukhova O.S., Chernenko S.V. Features of the dental status of children with congenital cleft lip and palate in permanent

occlusion. Dentistry of Childhood and Prevention. 2004;3(3–4):34–36. (In Russ.). Available at: https://www.elibrary.ru/

item.asp?id=9284441

Yatskevich E.E., Osokina G.G. Chronic gingivitis in children with hereditary and congenital somatic pathology. Dentistry

for Everyone. 2007;1:4–7. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=12516681

Chuikin S.V., Akat’eva G.G., Chuikin O.S., Grin’ E.A., Kuchuk K.N. Dental morbidity in children with congenital cleft

lip and palate in a region with ecotoxicants. Dentistry of Childhood and Prevention. 2019;19(4):15–19. (In Russ.).

Available at: https://www.elibrary.ru/item.asp?id=42490586

Chuikin O.S., Davletshin N.A., Chuikin S.V., Akat’eva G.G., Kuchuk K.N., Ganieva R.A., Muratov A.M. State of

periodontal tissues in children with congenital cleft palate and defect after uranoplasty. Actual Problems in Dentistry.

;17(4):105–112. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=47871063

Chopra A., Lakhanpal M., Rao N.C., Gupta N., Vashisth S. Oral health in 4–6-year-old children with cleft lip/palate: a

case-control study. N Am J Med Sci. 2014;6(6):266–269. doi: 10.4103/1947-2714.134371

Stelzle F., Rohde M., Oetter N., Krug K., Riemann M., Adler W. Gingival esthetics and oral health-related quality of life in

patients with cleft lip and palate. Int J Oral Maxillofacial Surgery. 2017;46(8):993–997. doi: 10.1016/j.ijom.2017.03.020

Funahashi K., Shiba T., Watanabe T., Nakagawa I., Moriyama K. Functional dysbiosis within dental plaque microbiota

in cleft lip and palate patients. Progress in Orthodontics. 2019;20(1):11. doi: 10.1186/s40510-019-0265-1

Malay K.K., Ravindran V., Kumar J. Gingival health status in children with and without cleft lip and palate: a casecontrol

study. Indian Journal of Forensic Medicine & Toxicology. 2020;14(4):5997–6003.

Genco R.J., Borgnakke W.S. Risk factors for periodontal disease. Periodontol 2000. 2013;62:59–94. doi: 10.1111/j.1600-

2012.00457.x

Bril E.A., Zubareva E.V., Yakimov K.Yu., Chizhov Yu.V,. Galonsky V.G. Experience in the treatment of chronic gingivitis

in adolescents with dental anomalies and deformities. Institute of Dentistry. 2021;4(93):86–87. (In Russ.). Available at:

https://www.elibrary.ru/item.asp?id=47486941

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Published

2026-01-01

How to Cite

Anvarova , M. (2026). ORAL FLUID BIOCHEMICAL AND PHYSICOCHEMICAL CHARACTERISTICS IN CHILDREN WITH ABNORMALITIES AFTER URANOPLASTY. Innovation Science and Technology, 2(1). https://doi.org/10.5281/zenodo.18472765
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