NEPHROGENIC ANEMIA AS A RISK FACTOR FOR THE DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Authors

DOI:

https://doi.org/10.5281/zenodo.17447255

Abstract

A total of 260 children with chronic kidney disease (CKD) were examined. Anemia was present in 217 patients,
accounting for 83.5%, and among children with cardiovascular disorders, it was observed in 90.2% of cases (110 out of
122 patients). The interrelation between cardiovascular disorders, CKD, and anemia lies in the fact that anemia affects
the course of CKD and the development of cardiovascular pathology. Anemia in children with CKD plays a key role in
the pathogenesis of cardiovascular damage through hypoxic injury to the myocardium. Restoration of hemoglobin levels
is essential even at the early stages of CKD, as it is crucial for preventing cardiovascular complications, which are the
leading cause of death among children and adolescents with CKD.

Keywords

Nephrogenic Anemia, Chronic Kidney Disease (CKD), Cardiovascular Disorders, Children, Risk Factor, Erythropoietin (EPO), Iron Deficiency, Hypertension, Left Ventricular Hypertrophy, Cardiovascular Morbidity.

References

1. Aitbaev K.A., Murkamilov I.T., Fomin V.V. Nephrogenic anemia: new physiological approaches to therapy based on

2. hypoxia-mimicking strategies. Almanac of Clinical Medicine. 2017 Nov; 45(7): 565–574. doi: 10.18786/2072-0505-

3. -45-7-565-574

4. Aksenova M.E. Mechanisms of cardiovascular pathology in chronic kidney disease. Practical Medicine. 2018. Vol. 16,

5. No. 8, pp. 21–26.

6. Savenkova N.D., Grigoryeva O.P. Prognosis of cardiovascular complications and renal failure in pediatric CKD patients

7. based on NKF-K/DOQI (2002) and KDIGO (2012) classifications. Russian Bulletin of Perinatology and Pediatrics.

8. ; 67(2): 12–19.

9. Sedov D.S. Cardiac remodeling in patients with chronic kidney disease (review). Saratov Journal of Medical Scientific

10. Research. 2019. Vol. 15, No. 2, pp. 217–221.

11. Yuldashev B.A., Shamsiev A.M. Echocardiography in the diagnosis of cardiovascular disorders in children with CKD.

12. New Day in Medicine – 2024. No. 10 (72), pp. 159–163.

13. Yuldashev B.A. Pathomorphological features of myocardial remodeling depending on the progression of CKD in

14. children. Problems of Biology and Medicine – 2024. No. 5, pp. 270–272.

15. Atkinson M.A., White C.T. Hepcidin in anemia of chronic kidney disease: review for the pediatric nephrologist. Pediatr

16. Nephrol. 2012 Jan; 27(1): 33–40. doi: 10.1007/s00467-011-1832-y. Epub 2011 Mar 13. PMID: 2140018

17. Chesnaye N.C., Schaefer F., Groothoff J.W., et al. Mortality risk in European children with end-stage renal disease on

18. dialysis. Kidney International. 2016; 89: 1355–1362.

19. Gerson A., Hwang W., Fiorenza J., et al. Anemia and health-related quality of life in adolescents with chronic kidney

20. disease. Am J Kidney Dis. 2004 Dec; 44(6): 1017–1023. doi: 10.1053/j.ajkd.2004.08.024. PMID: 15558522

21. Jelkmann W. Regulation of erythropoietin production. J Physiol. 2011 Mar 15; 589 (Pt 6): 1251–1258. doi: 10.1113/

22. jphysiol.2010.195057. Epub 2010 Nov 15. PMID: 21078592; PMCID: PMC3082088

23. Mitsnefes M.M. Cardiovascular disease in children with chronic kidney disease. J Am Soc Nephrol. 2012; 23: 578–585.

24. Perlman R.L., Finkelstein F.O., Liu L., et al. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis

25. in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005; 45(4): 658–666. [PubMed: 15806468]

Downloads

Published

2025-06-25

How to Cite

Aralov Mirza Dzhurakulovich. (2025). NEPHROGENIC ANEMIA AS A RISK FACTOR FOR THE DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN CHILDREN WITH CHRONIC KIDNEY DISEASE. Innovation Science and Technology, 1(7), 6–9. https://doi.org/10.5281/zenodo.17447255
Vol. 1 No. 7 (2025): Innovation Science and Technology